Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors

被引：27

作者：

Bordier, P

Garrigue, S

Barold, SS

Bressolles, N

Lanusse, S

Clémenty, J

机构：

[1] Univ Bordeaux, Hop Cardiol Haut Leveque, F-33604 Pessac, France

[2] Florida Cardiovasc Inst, Tampa, FL USA

[3] Tampa Gen Hosp, Tampa, FL 33606 USA

来源：

EUROPACE | 2003年 / 5卷 / 04期

关键词：

Alzheimer's disease; cholinesterase inhibitors; bradycardia;

D O I：

10.1016/S1099-5129(03)00080-1

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil). Bradyarrhythmia was documented in two patients, considered probable in one, and was presumed related to the cholinergic therapy. Pacemaker implantation seemed justified rather than donepezil cessation. More over, it permitted an increase in donepezil dosage. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：429 / 431

页数：3

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