Contractile agonists preferentially activate CL(-) over K+ currents in arterial myocytes

被引：29

作者：

Bakhramov, A ^{[1
]}

Hartley, SA ^{[1
]}

Salter, KJ ^{[1
]}

Kozlowski, RZ ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 227卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/bbrc.1996.1484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simultaneous patch-clamp and Ca2+ fluorescence measurements have revealed depolarising oscillations in the membrane potential of arterial (pulmonary) myocytes in response to adenosine 5'-triphosphate (ATP) and endothelin-1 (ET-1). These oscillations (i) are due to the preferential activation of Ca2+-activated Cl-, over K+ currents, (ii) occur through a mechanism involving Ca2+ release from intracellular Ca2+ stoles and (iii) are Likely to promote constriction, These results provide a novel perspective into the relative contribution and importance of Ca(2+)activated Cl- and K+ channels in controlling membrane potential of arterial smooth muscle in response to contractile agonists. (C) 1996 Academic Press, Inc.

引用

页码：168 / 175

页数：8

共 14 条

[1] DIFFERENTIAL K+ CHANNEL DISTRIBUTION IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PULMONARY ARTERIAL TREE OF THE RAT [J].