1H-Benzotriazol-1-yl methanesulfonate:: A regioselective N-mesylating reagent

被引：10

作者：

Kim, SY

Sung, ND

Choi, JK

Kim, SS ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305343, South Korea

[2] Chungnam Natl Univ, Div Appl Biol & Chem, Taejon 305764, South Korea

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 01期

关键词：

benzotriazoles; amines; sulfonamides; regioselection;

D O I：

10.1016/S0040-4039(98)80034-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1H-Benzotriazol-1-yl methanesulfonate has been found to be an effective reagent in selective mesylation for differentiating amino groups from one another. In a molecule with both primary and secondary amino groups, mesylation only occurred at the primary amino group. When a compound contains both amino and hydroxy groups, the reagent selectively mesylated at the amino groups. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

共 12 条

[1]

ACHIWA K, 1990, CHEM LETT, P999

[2]

Cho SY, 1996, HETEROCYCLES, V43, P1641

[3] 6-NITRO-1-BETA-NAPHTHALENESULFONYLOXYBENZOTRIAZOLE - A NOVEL COUPLING REAGENT FOR PEPTIDE-SYNTHESIS [J].