Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

被引：494

作者：

Marigo, Ilaria ^{[2
,4
]}

Dolcetti, Luigi ^{[2
,4
]}

Serafini, Paolo

Zanovello, Paola ^{[1
,2
,3
]}

Bronte, Vincenzo ^{[1
]}

机构：

[1] IRCCS, Ist Oncol Veneto, I-35128 Padua, Italy

[2] Univ Padua, Dept Oncol & Surg Sci, Padua, Italy

[3] Dodson Interdisciplinary Immunotherapy Inst, Dept Microbiol & Immunol, Miami, FL USA

[4] Venetian Inst Mol Med, Padua, Italy

来源：

IMMUNOLOGICAL REVIEWS | 2008年 / 222卷

关键词：

MDSC; tolerance; immunosuppression; arginine metabolism; cancer;

D O I：

10.1111/j.1600-065X.2008.00602.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the complex interplay of tumor-derived factors and deviant host properties, which involve a wide range of immune elements in the lymphoid and myeloid compartments. Regulatory lymphocytes, tumor-conditioned myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, and dysfunctional and immature dendritic cells take part in a complex immunoregulatory network. Despite the fact that some mechanisms governing tumor-induced immune tolerance and suppression are starting to be better understood and their complexity dissected, little is known about the diachronic picture of immune tolerance. Based on observations of MDSCs, we present a time-structured and topologically consistent idea of tumor-dependent tolerance progression in tumor-bearing hosts.

引用

页码：162 / 179

页数：18

共 163 条

[1] Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer [J].