A myelo-architectonic method for the structural classification of cortical areas

被引：85

作者：

Annese, J

Pitiot, A

Dinov, ID

Toga, AW

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA

[3] INRIA, EPIDAURE Lab, F-06902 Sophia Antipolis, France

[4] Dartmouth Coll, Ctr Cognit Neurosci, Hanover, NH 03755 USA

来源：

NEUROIMAGE | 2004年 / 21卷 / 01期

关键词：

myelo-architecture; cerebral cortex; cortical areas;

D O I：

10.1016/j.neuroimage.2003.08.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe an automatic and reproducible method to analyze the histological design of the cerebral cortex as applied to brain sections stained to reveal myelinated fibers. The technique provides an evaluation of the distribution of myelination across the width of the cortical mantle in accordance with a model of its curvature and its intrinsic geometry. The profile lines along which the density of staining is measured are generated from the solution of a partial differential equation (PDE) that models the intermediate layers of the cortex. Cortical profiles are classified according to significant components that emerge from wavelet analysis. Intensity profiles belonging to each distinct class are normalized and averaged to produce area-specific templates of cortical myelo-architecture. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：15 / 26

页数：12

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