Proteomic identification of activin receptor-like kinase-1 as a differentially expressed protein during hyaloid vascular system regression

被引：6

作者：

Albè, E

Escalona, E

Rajagopal, R

Javier, JA

Chang, JH

Azar, DT

机构：

[1] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA

[2] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA

[3] Schepens Eye Res Inst, Boston, MA 02114 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 25期

关键词：

activin receptor-like kinase-1; hyaloid vascular system regression;

D O I：

10.1016/j.febslet.2005.08.078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-beta 1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：5481 / 5486

页数：6

共 41 条

[1] Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin transforming growth factor-beta receptors in human pituitary adenomas [J].