Sublingual and oral immunotherapy

被引:10
作者
Canonica, GW [1 ]
Compalati, E [1 ]
Fumagalli, F [1 ]
Passalacqua, G [1 ]
机构
[1] Univ Genoa, Dept Internal Med, I-16132 Genoa, Italy
关键词
D O I
10.1016/j.iac.2004.07.001
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Sublingual immunotherapy (SLIT) is a viable alternative to the subcutaneous route for the treatment of respiratory allergy, whereas the pure oral route has been abandoned because of its lack of efficacy. The main distinctive feature of SLIT is its optimal safety profile, which has been demonstrated in adults and children. The indications for SLIT are similar to those for the subcutaneous route. A long-lasting effect has been demonstrated for the sublingual route, but data are needed to determine the optimal dose and the preventive effect in asthma.
引用
收藏
页码:685 / +
页数:21
相关论文
共 127 条
[1]   Mechanisms of allergen-specific immunotherapy [J].
Akdis, CA ;
Blaser, K .
ALLERGY, 2000, 55 (06) :522-530
[2]  
Almagro E, 1995, Allergol Immunopathol (Madr), V23, P153
[3]   Safety of sublingual-swallow immunotherapy in children and adults [J].
André, C ;
Vatrinet, C ;
Galvain, S ;
Carat, F ;
Sicard, H .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2000, 121 (03) :229-234
[4]   A double-blind placebo-controlled evaluation of sublingual immunotherapy with a standardized ragweed extract in patients with seasonal rhinitis -: Evidence for a dose-response relationship [J].
André, C ;
Perrin-Fayolle, M ;
Grosclaude, M ;
Couturier, P ;
Basset, D ;
Cornillon, J ;
Piperno, D ;
Girodet, B ;
Sanchez, R ;
Vallon, C ;
Bellier, P ;
Nasr, M .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2003, 131 (02) :111-118
[5]  
[Anonymous], 1986, Br Med J (Clin Res Ed), V293, P948
[6]  
Ariano R, 2001, Allergol Immunopathol (Madr), V29, P238
[7]   Absorption and distribution kinetics of the major Parietaria judaica allergen (Par j 1) administered by noninjectable routes in healthy human beings [J].
Bagnasco, M ;
Mariani, G ;
Passalacqua, G ;
Motta, C ;
Bartolomei, M ;
Falagiani, P ;
Mistrello, G ;
Canonica, GW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (01) :122-129
[8]   Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers [J].
Bagnasco, M ;
Passalacqua, G ;
Villa, G ;
Augeri, C ;
Flamigni, G ;
Borini, E ;
Falagiani, P ;
Mistrello, G ;
Canonica, GW ;
Mariani, G .
CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (01) :54-60
[9]   Efficacy of sublingual immunotherapy in children with asthma and rhinitis:: A double-blind, placebo-controlled study [J].
Bahçeciler, NN ;
Isik, U ;
Barlan, IB ;
Basaran, MM .
PEDIATRIC PULMONOLOGY, 2001, 32 (01) :49-55
[10]   The kinetics of change in cytokine production by CD4+T cells during conventional allergen immunotherapy [J].
Benjaponpitak, S ;
Oro, A ;
Maguire, P ;
Marinkovich, V ;
DeKruyff, RH ;
Umetsu, DT .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (03) :468-475