A controlled study of intravenous immunoglobulin in demyelinating neuropathy with IgM gammopathy

被引：148

作者：

Dalakas, MC ^{[1
]}

Quarles, RH ^{[1
]}

Farrer, RG ^{[1
]}

Dambrosia, J ^{[1
]}

Soueidan, S ^{[1
]}

Stein, DP ^{[1
]}

Cupler, E ^{[1
]}

Sekul, EA ^{[1
]}

Otero, C ^{[1
]}

机构：

[1] NINCDS, MOL & CELLULAR NEUROBIOL LAB, MYELIN & BRAIN DEV SECT, NIH, BETHESDA, MD USA

来源：

ANNALS OF NEUROLOGY | 1996年 / 40卷 / 05期

关键词：

D O I：

10.1002/ana.410400516

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eleven patients with demyelinating polyneuropathy associated with monoclonal IgM antibodies were randomized to receive IVIg or placebo, monthly, for 3 months in a double-blind study. After a washout period, they crossed over to the alternate therapy. Response was gauged by evaluating muscle strength, sensation, and neuromuscular symptoms at baseline, after 3 months, and at treatment's end. After IVIg therapy, the strength improved in only 2 of 11 patients, by 28 and 38.5 points from baseline, and declined after placebo. In 1 other patient, the sensory score improved by 13 points. Antibody titers to MAG/SGPG or gangliosides did not appreciably change. We conclude that Mg has only a modest benefit to not more than 18% of patients with IgM paraproteinemic demyelinating neuropathy.

引用

页码：792 / 795

页数：4

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