A basic fibroblast growth factor improved the quality of skin grafting in burn patients

被引:100
作者
Akita, S
Akino, K
Imaizumi, T
Hirano, A
机构
[1] Nagasaki Univ, Div Plast & Reconstruct Surg, Dept Dev & Reconstruct Med, Grad Sch Biomed & Sci, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Div Anat & Neurobiol, Dept Dev & Reconstruct Med, Grad Sch Biomed & Sci, Nagasaki 8528501, Japan
关键词
hypertrophic scar; basic fibroblast growth factor; skin grafting;
D O I
10.1016/j.burns.2005.04.008
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
To avoid hypertrophic scars in burn wounds, the simultaneous application of basic fibroblast growth factor (bFGF) with regular surgical debridement and skin grafting was investigated for skin hardness by clinical examination and instrumental measurement. As little is known about the role of bFGF in wounds, burn wound scars were tested for hardness. Burn scars in various anatomical locations at least I year after final wound healing clinically demonstrated a significantly lower hard score in bFGF-treated wounds than in non-bFGF wounds (0.95 +/- 0.51 versus 2.3 +/- 0.66, respectively, p < 0.01). In addition, a durometer, which is widely used in industry to measure materials similar to skin, such as rubber and thread-balls, demonstrated a significantly lower reading in bFGF-treated wounds than in non-bFGF wounds (7.9 +/- 3.64 versus 15.5 +/- 4.39, bFGF versus non-bFGF, respectively, p < 0.01). The results demonstrated that burn wounds treated with clinically approved bFGF might contribute to a better cutaneous wound quality, at least in terms of hardness. (c) 2005 Elsevier Ltd and ISB1. All rights reserved.
引用
收藏
页码:855 / 858
页数:4
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