Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging

被引:265
作者
Moncada, Diego
Viola, Haydee
机构
[1] Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurosci, RA-1121 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, RA-1121 Buenos Aires, DF, Argentina
关键词
inhibitory avoidance; spatial novelty; behavioral tag; hippocampus; long-term memory; rats;
D O I
10.1523/JNEUROSCI.1083-07.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memory-promoting effect caused by novelty depends on activation of dopamine D-1/D-5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace.
引用
收藏
页码:7476 / 7481
页数:6
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