Directed deprotonation of 7-methyl-1-aminobenzotriazole:: an approach to ortho-substituted benzyne precursors

被引：7

作者：

Birkett, MA

Knight, DW

Giles, RG

Mitchell, MB

机构：

[1] Univ Nottingham, Dept Chem, Nottingham NG7 2RD, England

[2] SB Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 15期

关键词：

D O I：

10.1039/a803251c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lateral deprotonation bf N-Boc-1-amino-7-methylbenzotriazole 7 using BuLi-TMEDA leads to the synthetically useful dianion 18, which can be alkylated and which condenses smoothly with a range of aldehydes, ketones and epoxides to provide derivatives (19, 20 and 21 respectively), which are potentially useful in the generation of substituted benzynes.

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页码：2301 / 2305

页数：5

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