Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma

被引：17

作者：

Deng, XL ^{[1
]}

Chen, W ^{[1
]}

Cai, MY ^{[1
]}

Wei, DP ^{[1
]}

机构：

[1] Sichuan Univ, W China Med Ctr, Dept Immunol, Chengdu 610044, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2003年 / 9卷 / 08期

关键词：

D O I：

10.3748/wjg.v9.i8.1853

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To demonstrate whether class I MHC molecule, transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC). METHODS: We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of immunohistochemistry. RESULTS: The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP, which were different from other tumor cells. Furthermore, we found that HSP70 expressed not only in cellular cytoplasm, but also on the cell surface in HCC. CONCLUSION: Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.

引用

页码：1853 / 1855

页数：3

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