Motor protein control of ion flux is an early step in embryonic left-right asymmetry

被引:54
作者
Levin, M
机构
[1] Harvard Univ, Sch Dent Med, Cytokine Biol Dept, Forsyth Inst, Boston, MA 02115 USA
[2] Harvard Univ, Sch Dent Med, Dept Craniofacial & Dev Biol, Boston, MA 02115 USA
关键词
D O I
10.1002/bies.10339
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The invariant left-right asymmetry of animal body plans raises fascinating questions in cell, developmental, evolutionary, and neuro-biology. While intermediate mechanisms (e.g., asymmetric gene expression) have been well-characterized, very early steps remain elusive. Recent studies suggested a candidate for the origins of asymmetry: rotary movement of extracellular morphogens by cilia during gastrulation. This model is intellectually satisfying, because it bootstraps asymmetry from the intrinsic biochemical chirality of cilia. However, conceptual and practical problems remain with this hypothesis, and the genetic data is consistent with a different mechanism. Based on wide-ranging data on ion fluxes and motor protein action in a number of species, a model is proposed whereby laterality is generated much earlier, by asymmetric transport of ions, which results in pH/voltage gradients across the midline. These asymmetries are in turn generated by a new candidate for "step 1 ": asymmetric localization of electrogenic proteins by cytoplasmic motors. BioEssays 25:1002-1010,2003. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:1002 / 1010
页数:9
相关论文
共 89 条
[1]  
AFZELIUS B A, 1976, Science (Washington D C), V193, P317
[2]   Bilateral asymmetry of the inositol trisphosphate-mediated calcium signaling in two-cell ascidian embryos [J].
Albrieux, M ;
Villaz, M .
BIOLOGY OF THE CELL, 2000, 92 (3-4) :277-284
[3]   Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo [J].
Antczak, M ;
Van Blerkom, J .
MOLECULAR HUMAN REPRODUCTION, 1997, 3 (12) :1067-1086
[4]  
BARISONI L, 1995, AM J PATHOL, V147, P1728
[5]   Centrosome composition and microtubule anchoring mechanisms [J].
Bornens, M .
CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (01) :25-34
[6]   Overexpression of the Xenopus tight-junction protein claudin causes randomization of the left-right body axis [J].
Brizuela, BJ ;
Wessely, O ;
De Robertis, EM .
DEVELOPMENTAL BIOLOGY, 2001, 230 (02) :217-229
[7]  
BROWN NA, 1990, DEVELOPMENT, V109, P1
[8]  
Burdine RD, 2000, GENE DEV, V14, P763
[9]  
DANOS MC, 1995, DEVELOPMENT, V121, P1467
[10]   Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis [J].
Davidson, BP ;
Kinder, SJ ;
Steiner, K ;
Schoenwolf, GC ;
Tam, PPL .
DEVELOPMENTAL BIOLOGY, 1999, 211 (01) :11-26