Physiology and pathology of proteostasis in the early secretory compartment

被引：20

作者：

Anelli, Tiziana ^{[1
]}

Sitia, Roberto ^{[1
]}

机构：

[1] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Div Genet & Cell Biol, I-20132 Milan, Italy

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 05期

关键词：

B cell differentiation; ERAD; Protein condensation; Proteotoxicity; Russell bodies; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; FUNCTIONALLY RELATED PROTEINS; QUALITY-CONTROL; MUTANT ALPHA(1)-ANTITRYPSIN-Z; RUSSELL BODIES; ER STRESS; MISFOLDED PROCOLLAGEN; CELL DIFFERENTIATION; BINDING-SPECIFICITY;

D O I：

10.1016/j.semcdb.2010.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum (ER), the port of entry for proteins into the secretory pathway, is a multifunctional organelle emerging as a central integrator of numerous signalling pathways. The mechanisms that control proteostasis are integral part of this signalling network, providing cues for morphological and functional cell remodelling, proliferation, inflammation and cell death. The complexity of ER responses is exploited during physiological and pathological tissue development, cell differentiation and lifespan control. This essay outlines some of the mechanisms that link proteostasis within the early secretory compartment to signalling in development and disease. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：520 / 525

页数：6

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