L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women

被引:17
作者
Baecker, N
Boese, A
Schoenau, E
Gerzer, R
Heer, M
机构
[1] DLR, Inst Aerosp Med, D-51170 Cologne, Germany
[2] Univ Cologne, Childrens Hosp, Cologne, Germany
关键词
bone; nutrition; treatments; bone QCT; bone turnover markers;
D O I
10.1359/JBMR.041121
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
yABSTRACT: NO is an important regulator of bone turnover. L-Arginine, the natural precursor of NO, can enhance NO production. However, no effect Of L-arginine hydrochloride supplementation was found on bone metabolism or on BMD, bone mass, or bone structure of healthy postmenopausal women. Introduction: Recent studies indicate that NO exerts an anabolic effect on bone cell activity. The NO level of the human body can be elevated by administering pharmacological NO donors. Animal studies and the first human trial showed that NO donor administration had a positive effect on bone formation and a negative effect on bone resorption. L-arginine, the natural precursor of NO, can enhance NO production. This study was conducted to examine the effect of an oral L-arginine supplement on bone metabolism of healthy postmenopausal women. Materials and Methods: The participants in this study were 30 healthy, age-matched postmenopausal women, divided into two groups. For 6 months, one group (54.5 +/- 4.1 years; 66.3 +/- 10.5 kg) received a daily oral supplement with 18 g L-arginine hydrochloride (14.8 g free L-arginine). The other 15 volunteers (55.3 +/- 4.4 years; 64.2 +/- 9.1 kg) received 18 g dextrose as a placebo. To verify compliance, 24-h urinary excretion of nitrogen was analyzed for 2 consecutive days at baseline and after 2, 4, and 6 months. At baseline and after 2, 4, and 6 months of supplementation, blood was drawn for analysis of insulin-like growth factor-I (IGF-I) and biomarkers of bone metabolism. At baseline, after 6 months, and after 1 year, pQCT measurements were performed at trabecular and cortical sites of the radius and tibia. The two groups of subjects were compared by repeated measures ANOVA. Results: As expected, in the group with L-arginine hydrochloride supplementation, nitrogen excretion rose, and in the placebo group, it remained constant. Only bone formation marker, procollagen type I propeptides (PICP), increased significantly (p < 0.05) after 6 months Of L-arginine supplementation. The results from pQCT showed no significant changes at any site in either group. No significant change in lGF-I concentration, which might have been caused by the L-arginine hydrochloride supplementation, was evident. Conclusions: We conclude from these results that supplementation with L-arginine hydrochloride is not effective for improving bone mass in humans.
引用
收藏
页码:471 / 479
页数:9
相关论文
共 61 条
[1]  
Alkalay RN, 2004, J BONE MINER RES, V19, pS318
[2]   Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial [J].
Baecker, N ;
Tomic, A ;
Mika, C ;
Gotzmann, A ;
Platen, P ;
Gerzer, R ;
Heer, M .
JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (03) :977-982
[4]   Early response in biochemical markers predicts long-term response in bone mass during hormone replacement therapy in early postmenopausal women [J].
Bjarnason, NH ;
Christiansen, C .
BONE, 2000, 26 (06) :561-569
[5]   Endocrine and lipid effects of oral L-arginine treatment in healthy postmenopausal women [J].
Blum, A ;
Cannon, RO ;
Costello, R ;
Schenke, WH ;
Csako, G .
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2000, 135 (03) :231-237
[6]   L-arginine-induced vasodilation in healthy humans:: Pharmacokinetic-pharmacodynamic relationship [J].
Bode-Böger, SM ;
Böger, RH ;
Galland, A ;
Tsikas, D ;
Frölich, JC .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 46 (05) :489-497
[7]   L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia - A randomized, controlled study [J].
BodeBoger, SM ;
Boger, RH ;
Alfke, H ;
Heinzel, D ;
Tsikas, D ;
Creutzig, A ;
Alexander, K ;
Frolich, JC .
CIRCULATION, 1996, 93 (01) :85-90
[8]   Language politics and flood control in nineteenth-century Montreal [J].
Boone, CG .
ENVIRONMENTAL HISTORY, 1996, 1 (03) :70-85
[9]   BIDIRECTIONAL REGULATION OF OSTEOCLAST FUNCTION BY NITRIC-OXIDE SYNTHASE ISOFORMS [J].
BRANDI, ML ;
HUKKANEN, M ;
UMEDA, T ;
MORADIBIDHENDI, N ;
BIANCHI, S ;
GROSS, SS ;
POLAK, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2954-2958
[10]   The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run [J].
Buchman, AL ;
O'Brien, W ;
Ou, CN ;
Rognerud, C ;
Alvarez, M ;
Dennis, K ;
Ahn, C .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 1999, 20 (05) :315-321