The VEGF family in cancer and antibody-based strategies for their inhibition

被引：179

作者：

Sullivan, Laura A. ^{[1
,2
]}

Brekken, Rolf A. ^{[1
,2
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Surg, Div Surg Oncol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

MABS | 2010年 / 2卷 / 02期

关键词：

VEGF; VEGF receptors; antibodies; cancer therapy; ENDOTHELIAL GROWTH-FACTOR; RECEPTOR TYROSINE KINASE; RENAL-CELL CARCINOMA; MONOCLONAL-ANTIBODY; SIGNAL-TRANSDUCTION; TUMOR ANGIOGENESIS; CRYSTAL-STRUCTURE; MOLECULAR REGULATION; ANGSTROM RESOLUTION; LIVER KINASE-1;

D O I：

10.4161/mabs.2.2.11360

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Angiogenesis is required in normal physiological processes, but is also involved in tumor growth, progression and metastasis. Vascular endothelial growth factor (VEGF), a primary mediator of angiogenesis in normal physiology and in disease, and other VEGF family members and their receptors provide targets that have been explored extensively for cancer therapy. Small molecule inhibitors and antibody/protein-based strategies that target the VEGF pathway have been studied in multiple types of cancer. This review will focus on VEGF pathway targeting antibodies that are currently being evaluated in pre-clinical and clinical studies.

引用

页码：165 / 175

页数：11

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