Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes

被引:18
作者
von Wronski, MA
Hirano, K
Cagen, LM
Wilcox, HG
Raghow, R
Thorngate, FE
Heimberg, M
Davidson, NO
Elam, MB
机构
[1] Univ Tennessee, Ctr Hlth Sci, Dept Pharmacol, Memphis, TN 38163 USA
[2] Univ Tennessee, Ctr Hlth Sci, Dept Med, Div Clin Pharmacol, Memphis, TN 38163 USA
[3] SUNY Stony Brook, Hlth Sci Ctr, Dept Pharmacol Sci, Stony Brook, NY USA
[4] Univ Chicago, Dept Med, Chicago, IL 60637 USA
[5] Memphis Vet Adm Med Ctr, Memphis, TN USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1998年 / 47卷 / 07期
关键词
D O I
10.1016/S0026-0495(98)90128-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have previously shown that chronic insulin treatment of rat hepatocytes increases the fraction of edited apolipoprotein B (apoB) mRNA from approximately 50% to as much as 90%. We have now examined the effect of insulin on apobec-1 mRNA abundance and demonstrate that increased editing of apoB mRNA following insulin treatment is accompanied by elevated apobec-1 mRNA levels in primary rat hepatocytes. Time-course measurements of the effects of insulin on apoB mRNA editing and apobec-1 mRNA abundance showed that both were elevated almost maximally within 48 hours and sustained for at least 5 days of insulin treatment. Copyright (C) 1998 by W.B. Saunders Company.
引用
收藏
页码:869 / 873
页数:5
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