Characterization of the Wiskott-Aldrich syndrome protein and its role in the disease

被引：29

作者：

Nonoyama, S

Ochs, HD

机构：

[1] Tokyo Med & Dent Univ, Sch Med, Dept Pediat, Bunkyo Ku, Tokyo 1138519, Japan

[2] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(98)80113-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wiskott-Aldrich syndrome is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. The Wiskott-Aldrich syndrome protein and the gene that encodes it have been identified by positional cloning and the protein has been shown to contain a pleckstrin-homology domain, a GTPase-binding domain, a proline-rich region and a verprolin/cofilin homology domain. Subsequent studies suggest that the protein is involved in signal transduction and the regulation of the cytoskeleton.

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页码：407 / 412

页数：6

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