Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

被引：54

作者：

Tamai, E

Ishida, T

Miyata, S

Matsushita, O

Suda, H

Kobayashi, S

Sonobe, H

Okabe, A

机构：

[1] Kagawa Med Univ, Fac Med, Dept Microbiol, Kagawa 7610793, Japan

[2] Kagawa Med Univ, Fac Med, Dept Anat, Kagawa 7610793, Japan

[3] Kagawa Med Univ, Fac Med, Dept Diagnost Pathol, Kagawa 7610793, Japan

[4] Natl Fukuyama Hosp, Dept Lab Med & Pathol, Fukuyama, Hiroshima 7208520, Japan

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 09期

关键词：

D O I：

10.1128/IAI.71.9.5371-5375.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

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页码：5371 / 5375

页数：5

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