Circulating endothelial progenitor cells in subjects with erectile dysfunction

被引:79
作者
Foresta, C
Caretta, N
Lana, A
Cabrelle, A
Palù, G
Ferlin, A
机构
[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Sect Microbiol & Virol, I-35121 Padua, Italy
[2] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Ctr Male Gamete Cryopreservat, I-35121 Padua, Italy
[3] Univ Padua, Dept Clin & Expt Med, I-35121 Padua, Italy
关键词
circulating endothelial progenitor cells; erectile dysfunction;
D O I
10.1038/sj.ijir.3901311
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Erectile dysfunction (ED) is often the first clinical sign of endothelial dysfunction and may precede overt cardiovascular diseases. Bone marrow-derived endothelial progenitor cells migrate into the peripheral circulation to promote endothelial repair. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The objective of our study was to determine the number of these cells in patients with ED both with and without cardiovascular risk factors. These subjects have lower number of circulating progenitor cells, confirming the existence of an endothelial dysfunction and supplying the evidence that ED may be the first symptom of an endothelial damage.
引用
收藏
页码:288 / 290
页数:3
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