The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat

被引:15
作者
Frost, P
Bornstein, S
Ehrhart-Bornstein, M
O'Kirwan, F
Hutson, C
Heber, D
Go, V
Licinio, J
Wong, ML
机构
[1] Univ Calif Los Angeles, Inst Neuropsychiat, Lab Pharmacogenom, David Geffen Sch Med, Los Angeles, CA USA
[2] Univ Dusseldorf, Dept Endocrinol, Dusseldorf, Germany
[3] Univ Calif Los Angeles, Ctr Dietary Supplement Res Bot, Ctr Human Nutr, Dept Med,David Geffen Sch Med, Los Angeles, CA USA
关键词
major depressive disorder; stress; ACTH; corticosterone;
D O I
10.1055/s-2003-43507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dysregulation in corticotropin-releasing hormone (CRH) secretion in the hypothalamus-pituitary-adrenal (HPA) axis may be involved in the etiology of major depressive disorder (MDD). Chronic therapy with standard antidepressant drugs, such as imipramine, can downregulate HPA axis function, indicating that the HPA axis may be an important target for antidepressant action. We tested several doses of a standardized commercial preparation of Hypericum perforatum plant extract (popularly known as St. John's Wort), a medicinal herb used for treating mild depressive symptoms, to determine whether it also modulated HPA axis function. Chronic imipramine treatment (daily injections for 8 weeks) of male Sprague-Dawley rats significantly downregulated circulating plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone compared to animals treated with saline. However, chronic St. John's Wort treatment (daily gavage for 8 weeks) had no effect on plasma ACTH or corticosterone, even at the highest doses tested. Our results confirm previous findings that imipramine may have significant peripheral HPA axis-mediated effects. However, our data does not support any role for H. perforatum in modulation of HPA axis function, suggesting that alternative pathways may be involved in mediating its antidepressant effects.
引用
收藏
页码:602 / 606
页数:5
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