Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation

被引:2553
作者
Herman, JG [1 ]
Baylin, SB
机构
[1] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA
关键词
D O I
10.1056/NEJMra023075
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2042 / 2054
页数:13
相关论文
共 131 条
  • [1] Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer
    Ahrendt, SA
    Chow, JT
    Xu, LH
    Yang, SC
    Eisenberger, CF
    Esteller, M
    Herman, JG
    Wu, L
    Decker, PA
    Jen, J
    Sidransky, D
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (04): : 332 - 339
  • [2] Ahuja N, 1998, CANCER RES, V58, P5489
  • [3] Antequera F., 1993, Experientia Supplementum (Basel), V64, P169
  • [4] Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    Bachman, KE
    Park, BH
    Rhee, I
    Rajagopalan, H
    Herman, JG
    Baylin, SB
    Kinzler, KW
    Vogelstein, B
    [J]. CANCER CELL, 2003, 3 (01) : 89 - 95
  • [5] Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    Bachman, KE
    Rountree, MR
    Baylin, SB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) : 32282 - 32287
  • [6] Bachman KE, 1999, CANCER RES, V59, P798
  • [7] Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
    Baylin, SB
    Esteller, M
    Rountree, MR
    Bachman, KE
    Schuebel, K
    Herman, JG
    [J]. HUMAN MOLECULAR GENETICS, 2001, 10 (07) : 687 - 692
  • [8] DNA hypermethylation in tumorigenesis - epigenetics joins genetics
    Baylin, SB
    Herman, JG
    [J]. TRENDS IN GENETICS, 2000, 16 (04) : 168 - 174
  • [9] Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
    Belinsky, SA
    Nikula, KJ
    Palmisano, WA
    Michels, R
    Saccomanno, G
    Gabrielson, E
    Baylin, SB
    Herman, JG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) : 11891 - 11896
  • [10] Bestor TH, 1998, CIBA F SYMP, V214, P187