Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5)

被引：83

作者：

Kato, Y ^{[1
]}

Ohyama, T ^{[1
]}

Mita, H ^{[1
]}

Yamamoto, Y ^{[1
]}

机构：

[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 28期

关键词：

D O I：

10.1021/ja050191b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3′-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of ∼1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin. Copyright © 2005 American Chemical Society.

引用

页码：9980 / 9981

页数：2

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