(-)-3,5-dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells:: through tyrosine kinase cascade signaling

被引：28

作者：

Hur, JY

Lee, P

Kim, H

Kang, I

Lee, KR

Kim, SY

机构：

[1] Kyung Hee Univ, Dept Herbal Pharmacol, Grad Sch EW Med Sci, Seoul 130701, South Korea

[2] Natl Inst Agr Sci & Technol, Dept Sericulture & Entomol, Suwon 441100, South Korea

[3] Kyung Hee Univ, Sch Med, Dept Biochem, Seoul 130701, South Korea

[4] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 313卷 / 04期

关键词：

(-)-3,5-dicaffeoyl-muco-quinic acid; PC12; neurite outgrowth; tyrosine kinase receptor; Erk; 1/2; PI3; kinase;

D O I：

10.1016/j.bbrc.2003.11.178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aster scaber T. (Asteraceae) has been used in traditional Korean and Chinese medicine to treat bruises, snakebites, headaches, and dizziness. (-)-3,5-Dicaffeoyl-muco-quinic acid (DQ) isolated from A. scaber induced neurite outgrowth in PC12 cells. It has been reported that the activation of the extracellular signal regulated kinase 1/2 (Erk 1/2) and phosphoinositide 3 (P13) kinase plays a crucial role in the NGF-induced differentiation of PC12 cells. This study showed that the effect of DQ on neurite outgrowth is mediated via the Erk 1/2 and P13 kinase-dependent pathways like NGF. Furthermore, DQ stimulated the phosphorylation of Trk A. Overall, DQ elicited the differentiation of PC12 cells through Trk A phosphorylation followed by Erk 1/2 and P13 kinase activation. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：948 / 953

页数：6

共 21 条

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