Time-dependent reversal of dentate LTP by 5 Hz stimulation

被引：27

作者：

Martin, SJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Neurosci, Edinburgh EH8 9LE, Midlothian, Scotland

来源：

NEUROREPORT | 1998年 / 9卷 / 17期

关键词：

depotentiation; hippocampus; long-term potentiation (LTP); low frequency stimulation;

D O I：

10.1097/00001756-199812010-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

FIELD potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro. NeuroReport 9: 3775-3781 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3775 / 3781

页数：7

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