Itk/Emt:: a link between T cell antigen receptor mediated Ca2+ events and cytoskeletal reorganization

被引：23

作者：

Tsoukas, CD ^{[1
]}

Grasis, JA

Ching, KA

Kawakami, Y

Kawakami, T

机构：

[1] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[2] San Diego State Univ, Inst Mol Biol, San Diego, CA 92182 USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

[4] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 01期

关键词：

D O I：

10.1016/S1471-4906(00)01795-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Itk/Emt, a tec family tyrosine kinase. is important for T-cell development and activation through the antigen receptor, Here, we review data suggesting that Ilk/Emt is involved in the generation of critical second messengers (Ca2+, PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.

引用

页码：17 / 20

页数：4

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