Screening of drug candidates for their drug-drug interaction potential

被引：50

作者：

Rodrigues, AD ^{[1
]}

Lin, JH ^{[1
]}

机构：

[1] Merck Res Labs, West Point, PA 19486 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00220-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the past year, additional papers have been published that focus on higher-throughput drug-interaction screening. Some papers have described enzyme assays that can be used to evaluate inhibition or induction of the human cytochrome P450s. At the same time, numerous investigators have developed computational (in silico) methods to predict interactions and have validated the approach using in vitro (assay-derived) data. These so called 'in silico-in vitro' correlations have great potential and may complement existing 'in vitro-in vivo' correlations.

引用

页码：396 / 401

页数：6

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