Development of the polymer micelle carrier system for doxorubicin

被引：455

作者：

Nakanishi, T

Fukushima, S

Okamoto, K

Suzuki, M

Matsumura, Y

Yokoyama, M

Okano, T

Sakurai, Y

Kataoka, K

机构：

[1] Nippon Kayaku Co Ltd, Drug Res Dept, Kita Ku, Tokyo 1158588, Japan

[2] Natl Canc Ctr Hosp, Dept Med, Chuo Ku, Tokyo 1040045, Japan

[3] Tokyo Womens Med Univ, Inst Biomed Engn, Shinjyuku Ku, Tokyo 1620054, Japan

[4] Univ Tokyo, Dept Mat Sci, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2001年 / 74卷 / 1-3期

关键词：

doxorubicin; anticancer drug; drug targeting; polymeric micelle;

D O I：

10.1016/S0168-3659(01)00341-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001. (C) 2001 Elsevier Science BY. All rights reserved.

引用

页码：295 / 302

页数：8

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