Enantioseparation of warfarin by capillary electrophoresis with UV and LIF detection using single and dual cyclodextrin type chiral selectors

被引：23

作者：

Chankvetadze, B

Burjanadze, N

Crommen, J

Blaschke, G

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

[2] Univ Liege, CHU, Inst Pharm, Dept Pharmaceut Analyt Chem, B-4000 Liege 1, Belgium

[3] Tbilisi State Univ, Sch Chem, Mol Recognit & Separat Sci Lab, GE-380028 Tbilisi, Georgia

来源：

CHROMATOGRAPHIA | 2001年 / 53卷 / Suppl 1期

关键词：

capillary electrophoresis; enantioseparations; chiral selectors; cyclodextrins;

D O I：

10.1007/BF02490345

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantioseparation of warfarin (WF) by capillary electrophoresis (CE) has been studied using various cyclodextrins (CD) such as native alpha, beta and gamma -CD, several neutral and randomly and selectively substituted charged CD derivatives. The enantiomer migration order of WF was determined with individual CDs. Various, CD combinations were used in order to enhance or diminish the separation factor in a designed way.

引用

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页码：S296 / S301

页数：6

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