Why do we not all have proteinuria?: An update of our current understanding of the glomerular barrier

被引：86

作者：

Haraldsson, B ^{[1
]}

Sörensson, J ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Nephrol, SE-41345 Gothenburg, Sweden

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷

关键词：

D O I：

10.1152/nips.01461.2003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The key question is not why some patients have proteinuria but rather why not all people have it. In the present review, we will present an update on the glomerular barrier after the recent breakthroughs in podocyte biology. In particular, we will discuss the role of the endothelium, which seems to be a neglected part of the glomerular membrane.

引用

页码：7 / 10

页数：4

共 20 条

[1]

Blouch K, 1997, AM J PHYSIOL-RENAL, V273, pF430

[2] Assessment of the charge selectivity of glomerular basement membrane using Ficoll sulfate [J].

Bolton, GR ;

Deen, WM ;

Daniels, BS .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1998, 274 (05) :F889-F896

[3] PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL .3. RESTRICTED TRANSPORT OF POLYANIONS [J].

CHANG, RLS ;

DEEN, WM ;

ROBERTSON, CR ;

BRENNER, BM .

KIDNEY INTERNATIONAL, 1975, 8 (04) :212-218

[4] Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule [J].

Christensen, EI ;

Birn, H .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (04) :F562-F573

[5]

Deen WM, 2001, AM J PHYSIOL-RENAL, V281, pF579

[6] Permeation of the luminal capillary glycocalyx is determined by hyaluronan [J].

Henry, CBS ;

Duling, BR .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (02) :H508-H514

[7] Puromycin aminonucleoside damages the glomerular size barrier with minimal effects on charge density [J].

Hjalmarsson, C ;

Ohlson, M ;

Haraldsson, B .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 281 (03) :F503-F512

[8]

JEANSSON B, IN PRESS J PHYSL REN

[9] Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome [J].

Kestila, M ;

Lenkkeri, U ;

Mannikko, M ;

Lamerdin, J ;

McCready, P ;

Putaala, H ;

Ruotsalainen, V ;

Morita, T ;

Nissinen, M ;

Herva, R ;

Kashtan, CE ;

Peltonen, L ;

Holmberg, C ;

Olsen, A ;

Tryggvason, K .

MOLECULAR CELL, 1998, 1 (04) :575-582

[10] Glomerular size and charge selectivity in the rat as revealed by FITC-Ficoll and albumin [J].

Ohlson, M ;

Sörensson, J ;

Haraldsson, B .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (01) :F84-F91

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