Cancer - Improved mouse models

被引:20
作者
Berns, A [1 ]
机构
[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands
关键词
D O I
10.1038/35074238
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
Mice that have been genetically modified to be prone to tumours are thought to be poor models of sporadic cancer. This problem can be tackled with a new generation of modified mice.
引用
收藏
页码:1043 / 1044
页数:2
相关论文
共 11 条
[1]
Use of reporter genes for optical measurements of neoplastic disease in vivo [J].
Contag, CH ;
Jenkins, D ;
Contag, FR ;
Negrin, RS .
NEOPLASIA, 2000, 2 (1-2) :41-52
[2]
Loss of heterozygosity in normal tissue adjacent to breast carcinomas [J].
Deng, GR ;
Lu, Y ;
Zlotnikov, G ;
Thor, AD ;
Smith, HS .
SCIENCE, 1996, 274 (5295) :2057-2059
[3]
Garcia SB, 1999, J PATHOL, V187, P61, DOI 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO
[4]
2-I
[5]
The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[6]
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice [J].
Johnson, L ;
Mercer, K ;
Greenbaum, D ;
Bronson, RT ;
Crowley, D ;
Tuveson, DA ;
Jacks, T .
NATURE, 2001, 410 (6832) :1111-1116
[7]
Lessons from hereditary colorectal cancer [J].
Kinzler, KW ;
Vogelstein, B .
CELL, 1996, 87 (02) :159-170
[8]
BEHAVIOR OF MYC AND RAS ONCOGENES IN TRANSFORMATION OF RAT EMBRYO FIBROBLASTS [J].
LAND, H ;
CHEN, AC ;
MORGENSTERN, JP ;
PARADA, LF ;
WEINBERG, RA .
MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (06) :1917-1925
[9]
Inducible gene targeting in mice using the Cre/lox system [J].
Sauer, B .
METHODS, 1998, 14 (04) :381-392
[10]
Differential distribution and increased levels of ras proteins during lung development [J].
Thrane, EV ;
Becher, R ;
Lag, M ;
Refsnes, M ;
Huitfeldt, HS ;
Schwarze, PE .
EXPERIMENTAL LUNG RESEARCH, 1997, 23 (01) :35-49