Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating Anti-HIV-1 antibodies and prognostic predictors of HIV infection

被引：131

作者：

Ahmad, R

Sindhu, STAK

Toma, E

Morisset, R

Vincelette, J

Menezes, J

Ahmad, A

机构：

[1] Hop St Justine, Lab Immunovirol, Pediat Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Hop Hotel Dieu, Montreal, PQ H2W 1T8, Canada

[3] Hop St Luc, Montreal, PQ H2X 1P1, Canada

[4] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ, Canada

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2001年 / 21卷 / 03期

基金：

加拿大健康研究院;

关键词：

antibody-dependent cellular cytotoxicity; AIDS; HIV-1; CD4+T cell counts; plasma HIV load;

D O I：

10.1023/A:1011087132180

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HN-l ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

引用

页码：227 / 233

页数：7

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