Identification of an HLA-C variant allele, Cw*0805, by sequencing based typing

被引：13

作者：

Dunn, PPJ ^{[1
]}

Day, S ^{[1
]}

Harvey, J ^{[1
]}

Fuggle, SV ^{[1
]}

Ross, J ^{[1
]}

机构：

[1] UKTSSA, Bristol BS34 8RR, Avon, England

来源：

TISSUE ANTIGENS | 1998年 / 52卷 / 06期

关键词：

Cw*0805; Cw*1602; HLA-C alleles; polymorphism;

D O I：

10.1111/j.1399-0039.1998.tb03092.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have identified a variant HLA-C allele, Cw*0805, in DNA isolated from a blood sample used in the UK National External Quality Assessment Scheme for Histocompatibility and Immunogenetics. The DNA was initially typed by PCR-SSP and PCR-SBT as Cw*0802, 1602 with a single mismatch in exon 2 of one of the alleles, The two HLA-C alleles were separated by locus- and allele-specific PCRs and sequencing analysis showed that the Cw*0802 allele was variant in this sample, with a single mismatch in exon 2 at position 289.

引用

页码：587 / 589

页数：3

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