Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination -: possible markers for an antibody-mediated process

被引：35

作者：

Brück, W

Neubert, K

Berger, T

Weber, JR

机构：

[1] Humboldt Univ, Charite, Dept Neuropathol, D-13353 Berlin, Germany

[2] Humboldt Univ, Charite, Dept Neurol, D-13353 Berlin, Germany

[3] Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria

来源：

MULTIPLE SCLEROSIS JOURNAL | 2001年 / 7卷 / 03期

关键词：

multiple sclerosis; antibody; plasmapheresis;

D O I：

10.1177/135245850100700307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present report describes immunopathological, radiological and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (I) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in TI-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.

引用

页码：173 / 177

页数：5

共 30 条

[1]

AARLI JA, 1975, IMMUNOLOGY, V28, P171

[2]

The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat [J].