Recent Developments in Myofibroblast Biology Paradigms for Connective Tissue Remodeling

被引：1017

作者：

Hinz, Boris ^{[1
]}

Phan, Sem H. ^{[2
]}

Thannickal, Victor J. ^{[3
]}

Prunotto, Marco ^{[4
]}

Desmouliere, Alexis ^{[5
]}

Varga, John ^{[6
]}

De Wever, Olivier ^{[7
]}

Mareel, Marc ^{[7
]}

Gabbian, Giulio ^{[8
]}

机构：

[1] Univ Toronto, Matrix Dynam Grp, Lab Tissue Repair & Regenerat, Fac Dent, Toronto, ON M5S 3E2, Canada

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA

[3] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

[4] F Hoffmann La Roche & Co Ltd, CV & Metab DTA Dept, CH-4002 Basel, Switzerland

[5] Univ Limoges, Dept Physiol, Fac Pharm, Limoges, France

[6] Northwestern Univ, Div Rheumatol, Feinberg Sch Med, Chicago, IL 60611 USA

[7] Ghent Univ Hosp, Lab Expt Canc Res, Dept Radiat Oncol & Expt Canc Res, Ghent, Belgium

[8] Univ Geneva, Dept Pathol & Immunol, Fac Med, Geneva, Switzerland

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2012年 / 180卷 / 04期

基金：

加拿大健康研究院; 瑞士国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

GROWTH-FACTOR-BETA; IDIOPATHIC PULMONARY-FIBROSIS; HEPATIC STELLATE CELLS; MUSCLE ALPHA-ACTIN; TELOPEPTIDE LYSYL HYDROXYLASE; SCLERODERMA SKIN FIBROBLASTS; TO-MESENCHYMAL TRANSITION; SYSTEMIC-SCLEROSIS; TGF-BETA; COLLAGEN EXPRESSION;

D O I：

10.1016/j.ajpath.2012.02.004

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

The discovery of the myofibroblast has opened new perspectives for the comprehension of the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, many advances have been made in understanding important aspects of myofibroblast basic biological characteristics. This review summarizes such advances in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; factors controlling the expression of alpha-smooth muscle actin, the most used marker of myofibroblastic phenotype and, more important, involved in force generation by the myofibroblast; and factors affecting genesis of the myofibroblast and its differentiation from precursor cells, in particular epigenetic factors, such as DNA methylation, microRNAs, and histone modification. We also review the origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors. Finally, we summarize the emerging Strategies for influencing myofibroblast behavior in vitro and in vivo, with the ultimate goal of an effective therapeutic approach for myofibroblast-dependent diseases. (Ant J Pathol 2012, 180: 1340-1355; DOI: 10.1016/j.ajpath.2012.02.004)

引用

页码：1340 / 1355

页数：16

共 169 条

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