Synthesis of hydantoins via N,N′-ureas derived from polymer-bound amino acids

被引：5

作者：

Bauser, M

Winter, M

Valenti, CA

Wiesmüller, KH

Jung, G

机构：

[1] Univ Tubingen, Inst Organic Chem, D-72076 Tubingen, Germany

[2] NMI Reutlingen, D-72768 Reutlingen, Germany

来源：

MOLECULAR DIVERSITY | 1998年 / 3卷 / 04期

关键词：

automated synthesis; combinatorial chemistry; hydantoins; imidazolidinediones; solid phase synthesis;

D O I：

10.1023/A:1009639804397

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting from carboxy-linked amino acids on trityl functionalized polystyrene resin a highly efficient solid-phase synthesis of hydantoins via N,N'-ureas was elaborated. The polymer-bound hydantoins can be used as scaffolds for further combinatorial transformations, such as alkylation. Cleavage from the resins yielded the corresponding hydantoins in good yields and purities as shown by ESI-MS and HPLC.

引用

页码：257 / 260

页数：4

共 10 条

[1]

Balkenhohl F., 1996, ANGEW CHEM, V108, P2436

[2] DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY [J].