Viral levels in newborn African infants undergoing primary HIV-1 infection

被引：18

作者：

Biggar, RJ ^{[1
]}

Broadhead, R

Janes, M

Kumwenda, N

Taha, TET

Cassol, S

机构：

[1] NCI, Viral Epidemiol Branch, Bethesda, MD 20892 USA

[2] Univ Malawi, Dept Paediat, Blantyre, Malawi

[3] Univ Ottawa, Ottawa, ON, Canada

[4] Johns Hopkins Univ Univ Malawi Project, Blantyre, Malawi

[5] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA

来源：

AIDS | 2001年 / 15卷 / 10期

关键词：

D O I：

10.1097/00002030-200107060-00015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined weekly changes in viral levels in seven untreated infants infected with HIV at birth. Viral levels spiked immediately but reverted quickly to plateau levels typical of infant HIV infection within 2 weeks of first detected viraemia. We speculated that the depletion of naive, susceptible cells is responsible for the rapid decrease in spike levels and that the rapid replacement of lymphocytes in infants causes the high plateau viral levels (10(5) copies/ml) to be sustained.

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页码：1311 / 1313

页数：3

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