Wnt/β-catenin signaling:: Turning the switch

被引：28

作者：

Cadigan, Ken M. ^{[1
]}

机构：

[1] Univ Michigan, Ann Arbor, MI 48109 USA

来源：

DEVELOPMENTAL CELL | 2008年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2008.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The regulation of many targets of the Wnt/beta-catenin signaling pathway is thought to occur through a transcriptional switch that is achieved by beta-catenin binding to TCF transcription factors. Recent work indicates that beta-catenin's intrinsic affinity for TCF is not sufficient for the switch to occur.

引用

页码：322 / 323

页数：2

共 5 条

[1]

LL J, 2008, NAT CELL BIOL, V10, P160

[2] Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses [J].