Shh and Ptc are associated with taste bud maintenance in the adult mouse

被引：86

作者：

Miura, H

Kusakabe, Y

Sugiyama, C

Kawamatsu, M

Ninomiya, Y

Motoyama, J

Hino, A

机构：

[1] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

[2] Kyushu Univ, Fac Dent, Higashi Ku, Fukuoka 8128582, Japan

[3] Bio Orineted Technol Res Advancement Inst, Minato Ku, Tokyo 105, Japan

[4] RIKEN, Inst Phys & Chem Res, Brain Sci Inst, Mol Neuropathol Grp, Wako, Saitama 3510198, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 106卷 / 1-2期

关键词：

taste bud; tongue; taste nerve; Sonic hedgehog; patched1; adult mouse;

D O I：

10.1016/S0925-4773(01)00414-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In mammals, taste receptor cells are organized into taste buds on tongue. Taste buds are trophically maintained by taste neurons and under continuous renewal, even in adults. We found that the receptor for Sonic hedgehog (Shh), Patched1 (Ptc), was expressed around taste buds where cells were proliferating, and that Shh was expressed within basal cells of taste buds. Denervation caused the loss of Shh and Ptc expression before the degeneration of taste buds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 145

页数：3

共 12 条

[1] Identification of taste-tissue-specific cDNA clones from a subtraction cDNA library of rat circumvallate and foliate papillae [J].