Coordination of Ca2+ signalling by NAADP

被引：127

作者：

Patel, S ^{[1
]}

Churchill, GC ^{[1
]}

Galione, A ^{[1
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(01)01896-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular Ca2+ stores in several cell types. Ample evidence suggests that NAADP activates intracellular Ca2+ channels distinct from those that are sensitive to inositol trisphosphate and ryanodine/cyclic ADP-ribose. Recent studies in intact cells have demonstrated functional coupling ('channel chatter') between Ca2+ release pathways mediated by NAADP inositol trisphosphate and cyclic ADP-ribose. Thus, NAADP is probably an important determinant in shaping cytosolic Ca2+ signals.

引用

页码：482 / 489

页数：8

共 59 条

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