Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

被引：59

作者：

Agrawal, Arpana ^{[1
]}

Hinrichs, Anthony L. ^{[1
]}

Dunn, Gerald ^{[1
]}

Bertelsen, Sarah ^{[1
]}

Dick, Danielle M. ^{[1
]}

Saccone, Scott F. ^{[1
]}

Saccone, Nancy L. ^{[1
]}

Grucza, Richard A. ^{[1
]}

Wang, Jen C. ^{[1
]}

Cloninger, C. Robert ^{[1
]}

Edenberg, Howard J. ^{[2
]}

Foroud, Tatiana ^{[2
]}

Hesselbrock, Victor ^{[3
]}

Kramer, John ^{[4
]}

Bucholz, Kathleen K. ^{[1
]}

Kuperman, Samuel ^{[5
]}

Numberger, John I., Jr. ^{[2
]}

Porjesz, Bernice ^{[6
]}

Schuckit, Marc A. ^{[7
]}

Goate, Alison M. ^{[1
]}

Bierut, Laura J. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA

[3] Univ Connecticut, Ctr Hlth, Farmington, CT 06030 USA

[4] Univ Iowa, Coll Med, Iowa City, IA 52242 USA

[5] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA

[6] SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA

[7] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

DRUG AND ALCOHOL DEPENDENCE | 2008年 / 93卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

linkage; alcohol; cannabis; illicit drugs; dependence; COGA;

D O I：

10.1016/j.drugalcdep.2007.08.015

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213 cM), 2 (3.4 at 234 cM) and 10 (3.7 at 60 cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95 cM on chromosome 14. For any illicit drug dependence, LODs of 2.0 and 2.4 were observed on chromosome 10 (116 cM) and 13 (64 cM) respectively. Finally, the combined alcohol and/or drug dependence symptoms yielded LODs >2.0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：12 / 20

页数：9

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