Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis

被引：39

作者：

Nataf, S ^{[1
]}

Davoust, N ^{[1
]}

Barnum, SR ^{[1
]}

机构：

[1] Univ Alabama, Dept Microbiol, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 91卷 / 1-2期

关键词：

complement; C5a receptor; experimental allergic encephalomyelitis; multiple sclerosis; central nervous system;

D O I：

10.1016/S0165-5728(98)00169-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we investigated the expression of the C5aR in spinal cords of Lewis rats with experimental allergic encephalomyelitis (EAE). Using in situ hybridization (ISH) we analyzed the kinetics of C5aR at different time points of EAE (preclinical stage, clinical peak, remission phase). We observed that C5aR mRNA was readily detected in the CNS of EAE rats at all the stages of the disease. Using a combination of ISH and immunohistochemistry, we formally demonstrated that C5aR is strongly expressed on microglial cells and hypertrophic astrocytes during EAE. The potential involvement of C5a receptor in EAE physiopathology is discussed. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：147 / 155

页数：9

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