Immunohistochemical evidence of the presence of aromatase P450 in the rat hypophysis

被引：34

作者：

Carretero, J ^{[1
]}

Vázquez, G ^{[1
]}

Blanco, E ^{[1
]}

Rubio, M ^{[1
]}

Santos, M ^{[1
]}

Martín-Clavijo, A ^{[1
]}

Torres, JL ^{[1
]}

Vázquez, R ^{[1
]}

机构：

[1] Fac Med, Dpto Anat & Histol Humanas, E-37007 Salamanca, Spain

来源：

CELL AND TISSUE RESEARCH | 1999年 / 295卷 / 03期

关键词：

hypophysis; aromatase; immunocytochemistry; morphometry; gender differences; rat (Sprague Dawley);

D O I：

10.1007/s004410051248

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In order to analyze whether aromatase is present in the hypophysis of adult rats, we have performed an immunohistochemical study in young adult male and female rats. Our study has revealed that the hypophysis of adult rats contains aromatase, although marked differences are found between the sexes. The hypophyses of male rats have cells immunoreactive for the enzyme, 34.40% of these hypophyseal cells showing reaction. By contrast, cells from female rats show very little reaction, only 0.84% of them being reactive. No significant differences in the percentage of immunoreactive cells between one phase and another are observed during the estrous cycle. Our results point to the immunohistochemical expression of aromatase in the hypophysis of adult rats and at the same time suggest that its expression is sex-dependent. The enzyme may therefore be involved in the regulation of adenohypophyseal cytology by androgens.

引用

页码：419 / 423

页数：5

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