Microvesicles in Health and Disease

被引：59

作者：

Inal, Jameel M. ^{[1
]}

Ansa-Addo, Ephraim A. ^{[1
]}

Stratton, Dan ^{[1
]}

Kholia, Sharad ^{[1
]}

Antwi-Baffour, Samuel S. ^{[1
]}

Jorfi, Samireh ^{[1
]}

Lange, Sigrun ^{[2
]}

机构：

[1] London Metropolitan Univ, Cellular & Mol Immunol Res Ctr, Fac Life Sci, London N7 8DB, England

[2] UCL, Perinatal Brain Repair Grp, Inst Womens Hlth, London, England

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2012年 / 60卷 / 02期

关键词：

Microvesicles; Intercellular transport; Cancer; Autoimmune disease; Stroke; Infectious disease; CELL-DERIVED MICROVESICLES; FACTOR-POSITIVE MICROPARTICLES; ACUTE ISCHEMIC-STROKE; MEMBRANE MICROPARTICLES; PLASMA-MEMBRANE; ENDOTHELIAL-CELLS; TISSUE-FACTOR; TGF-BETA; PLATELET MICROPARTICLES; ACTIVATED PLATELETS;

D O I：

10.1007/s00005-012-0165-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins, and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also summarised together with their possible use as therapeutic agents.

引用

页码：107 / 121

页数：15

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