Modular regulatory principles of large non-coding RNAs

被引：1911

作者：

Guttman, Mitchell ^{[1
,2
]}

Rinn, John L. ^{[1
,3
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Harvard Univ, Cambridge, MA 02138 USA

来源：

NATURE | 2012年 / 482卷 / 7385期

关键词：

X-CHROMOSOME INACTIVATION; OPEN READING FRAMES; XIST RNA; TRANSCRIPTIONAL ACTIVITY; CHROMATIN STATE; GENE-EXPRESSION; HUMAN GENOME; STEM-CELLS; INTERGENIC TRANSCRIPTION; HISTONE MODIFICATION;

D O I：

10.1038/nature10887

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

引用

页码：339 / 346

页数：8

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