Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

被引：72

作者：

Ahn, Bumsoo ^{[1
]}

Pharaoh, Gavin ^{[1
,2
]}

Premkumar, Pavithra ^{[1
]}

Huseman, Kendra ^{[1
]}

Ranjit, Rojina

Kinter, Michael ^{[1
,3
]}

Szweda, Luke ^{[1
]}

Kiss, Tamas ^{[3
]}

Fulop, Gabor ^{[3
,4
]}

Tarantini, Stefano ^{[3
,4
]}

Csiszar, Anna ^{[3
,4
]}

Ungvari, Zoltan ^{[3
,4
]}

Van Remmen, Holly ^{[1
,2
,5
]}

机构：

[1] Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK USA

[3] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK USA

[4] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Translat Gerosci Lab, Oklahoma City, OK USA

[5] Oklahoma City VA Med Ctr, Oklahoma City, OK USA

来源：

REDOX BIOLOGY | 2018年 / 17卷

关键词：

ELEVATED OXIDATIVE STRESS; CUZN-SUPEROXIDE-DISMUTASE; MITOCHONDRIAL-FUNCTION; IN-VIVO; GENE-EXPRESSION; HEART-FAILURE; ENZYME GENES; MICE; ATROPHY; EXERCISE;

D O I：

10.1016/j.redox.2018.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

[No abstract available]

引用

页码：47 / 58

页数：12

共 66 条

[1]

NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure [J].

Ahn, Bumsoo ;

Beharry, Adam W. ;

Frye, Gregory S. ;

Judge, Andrew R. ;

Ferreira, Leonardo F. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2015, 309 (05) :L497-L505

[2]

CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study [J].

Altara, Raffaele ;

Manca, Marco ;

Hessel, Marleen H. ;

Gu, Yumei ;

van Vark, Laura C. ;

Akkerhuis, K. Martijn ;

Staessen, Jan A. ;

Struijker-Boudier, Harry A. J. ;

Booz, George W. ;

Blankesteijn, W. Matthijs .

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2016, 9 (04) :302-314

[3]

Type II skeletal myofibers possess unique properties that potentiate mitochondrial H2O2 generation [J].

Anderson, EJ ;

Neufer, PD .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 290 (03) :C844-C851

[4]

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production [J].

Barton, Elisabeth R. ;

Park, SooHyun ;

James, Jose K. ;

Makarewich, Catherine A. ;

Philippou, Anastassios ;

Eletto, Davide ;

Lei, Hanqin ;

Brisson, Becky ;

Ostrovsky, Olga ;

Li, Zihai ;

Argon, Yair .

FASEB JOURNAL, 2012, 26 (09) :3691-3702

[5]

CONTRACTILE PROPERTIES OF SKELETAL-MUSCLES FROM YOUNG, ADULT AND AGED MICE [J].

BROOKS, SV ;

FAULKNER, JA .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :71-82

[6]

In vivo modulation of the Parkinsonian phenotype by Nrf2 [J].

Burton, Neal C. ;

Kensler, Thomas W. ;

Guilarte, Tomas R. .

NEUROTOXICOLOGY, 2006, 27 (06) :1094-1100

[7]

Differential variation of mitochondrial H2O2 release during aging in oxidative and glycolytic muscles in rats [J].

Capel, F ;

Buffière, C ;

Mirand, PP ;

Mosoni, L .

MECHANISMS OF AGEING AND DEVELOPMENT, 2004, 125 (05) :367-373

[8]

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein [J].

Chan, JY ;

Kwong, M .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1517 (01) :19-26

[9]

Sarcopenia Is Independently Associated with Cardiovascular Disease in Older Korean Adults: The Korea National Health and Nutrition Examination Survey (KNHANES) from 2009 [J].

Chin, Sang Ouk ;

Rhee, Sang Youl ;

Chon, Suk ;

Hwang, You-Cheol ;

Jeong, In-Kyung ;

Oh, Seungjoon ;

Ahn, Kyu Jeung ;

Chung, Ho Yeon ;

Woo, Jeong-taek ;

Kim, Sung-Woon ;

Kim, Jin-Woo ;

Kim, Young Seol ;

Ahn, Hong-Yup .

PLOS ONE, 2013, 8 (03)

[10]

Gene expression profiling of NRF2-mediated protection against oxidative injury [J].

Cho, HY ;

Reddy, SP ;

DeBiase, A ;

Yamamoto, M ;

Kleeberger, SR .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 38 (03) :325-343

← 1 2 3 4 5 6 7 →