Development of the Spatial Representation System in the Rat

被引：420

作者：

Langston, Rosamund F. ^{[1
,2
]}

Ainge, James A. ^{[1
,2
,3
]}

Couey, Jonathan J. ^{[1
,2
]}

Canto, Cathrin B. ^{[1
,2
]}

Bjerknes, Tale L. ^{[1
,2
]}

Witter, Menno P. ^{[1
,2
]}

Moser, Edvard I. ^{[1
,2
]}

Moser, May-Britt ^{[1
,2
]}

机构：

[1] Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, N-7489 Trondheim, Norway

[2] Norwegian Univ Sci & Technol, Ctr Biol Memory, Med Tech Res Ctr, N-7489 Trondheim, Norway

[3] Univ St Andrews, Sch Psychol, St Andrews KY16 9JP, Fife, Scotland

来源：

SCIENCE | 2010年 / 328卷 / 5985期

关键词：

ENTORHINAL CORTEX; PLACE CELLS; GRID CELLS; PATH-INTEGRATION; MAP; MODEL; HIPPOCAMPUS; DIRECTION;

D O I：

10.1126/science.1188210

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary map of space is already present when 21/2-week-old rat pups explore an open environment outside the nest for the first time. Head-direction cells in the pre- and parasubiculum have adultlike properties from the beginning. Place and grid cells are also present but evolve more gradually. Grid cells show the slowest development. The gradual refinement of the spatial representation is accompanied by an increase in network synchrony among entorhinal stellate cells. The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation.

引用

页码：1576 / 1580

页数：5

共 20 条

[1]

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