Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

被引：92

作者：

van de Sande, Marleen G. H. ^{[1
]}

Gerlag, Danielle M. ^{[1
]}

Lodde, Beatrijs M. ^{[1
]}

van Baarsen, Lisa G. M. ^{[1
]}

Alivernini, Stefano ^{[2
]}

Codullo, Veronica ^{[3
]}

Felea, Ioana ^{[4
]}

Vieira-Sousa, Elsa ^{[5
]}

Fearon, Ursula ^{[6
]}

Reece, Richard ^{[7
,11
]}

Montecucco, Carlomaurizio ^{[3
]}

Veale, Douglas J. ^{[6
]}

Pitzalis, Costantino ^{[8
]}

Emery, Paul ^{[7
,11
]}

Klareskog, Lars ^{[9
]}

McInnes, Iain B. ^{[10
]}

Tak, Paul P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, Room F4-218,POB 22700, NL-1100 DE Amsterdam, Netherlands

[2] Univ Cattolica Sacro Cuore, Div Rheumatol, Sch Med, I-00168 Rome, Italy

[3] Univ Pavia, Div Rheumatol, IRCCS Policlin San Matteo Fdn, I-27100 Pavia, Italy

[4] Univ Med & Pharm, Dept Rheumatol, Cluj Napoca, Romania

[5] Univ Lisbon, Rheumatol Res Unit, Inst Mol Med, Fac Med, P-1699 Lisbon, Portugal

[6] St Vincents Univ Hosp, Dept Rheumatol, Dublin 4, Ireland

[7] Leeds Inst Mol Med, Sect Musculoskeletal Dis, London, England

[8] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

[9] Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med, Stockholm, Sweden

[10] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow Biomed Res Ctr, Glasgow, Lanark, Scotland

[11] Leeds Teaching Hosp Trust, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2011年 / 70卷 / 03期

关键词：

MONOCLONAL-ANTIBODY TREATMENT; TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; CELL INFILTRATE; PSORIATIC-ARTHRITIS; GENE-EXPRESSION; DOUBLE-BLIND; TISSUE; INFLAMMATION; ARTHROSCOPY;

D O I：

10.1136/ard.2010.139550

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.

引用

页码：423 / 427

页数：5

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