Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain

被引：67

作者：

Sun, J ^{[1
]}

Tadokoro, S ^{[1
]}

Imanaka, T ^{[1
]}

Murakami, SD ^{[1
]}

Nakamura, M ^{[1
]}

Kashiwada, K ^{[1
]}

Ko, J ^{[1
]}

Nishida, W ^{[1
]}

Sobue, K ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Biomed Res Ctr, Dept Neurochem & Neuropharmacol, Osaka 5650871, Japan

来源：

FEBS LETTERS | 1998年 / 437卷 / 03期

关键词：

metabotropic glutamate receptor; receptor clustering; postsynaptic density; leucine zipper; PDZ domain;

D O I：

10.1016/S0014-5793(98)01256-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using monoclonal antibody against the 45 kDa postsynaptic density protein, we isolated a novel isoform of Homer/vesl, The NH2-terninal region containing a PDZ domain of this protein is identical to that of Homer/vesl, and the COOH-terminal region containing unique leucine zippers shows self-multimerization. We named this protein PSD-Zip45, In addition to specific binding of PSD-Zip45 mediated by a PDZ domain to the metabotropic glutamate receptors 1 alpha or 5, the distribution of PSD-Zip45 transcripts is highly consistent with that of metabotropic glutamate receptor transcripts. The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. (C) 1998 Federation of European Biochemical Societies.

引用

页码：304 / 308

页数：5

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