Synthesis of 2-amino-2′-diphenylphosphino-1,1′-binaphthyl (MAP) and its accelerating effect on the Pd(0)-catalyzed N-arylation

被引：52

作者：

Vyskocil, S ^{[1
]}

Smrcina, M

Kocovsky, P

机构：

[1] Charles Univ, Dept Organ Chem, Prague 12840 2, Czech Republic

[2] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(98)02088-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound 3, synthesized in four steps from NOBIN (1), has been found to exhibit a dramatic accelerating effect on the Pd(0)-catalyzed Hartwig-Buchwald N-phenylation of amino alcohol 1 and diamine 8 with PhBr. Partial kinetic resolution was observed for the phenylation of (+/-)-1 or (+)-8 in the presence of(S)-BINAP. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9289 / 9292

页数：4

共 32 条

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